Originally, inhabited by the Tchoupitoulas Indians, the area along the Mississippi River was the first land in the New Orleans Metropolitan Area on which Europeans set foot. René-Robert Cavelier, Sieur de La Salle landed there in 1682. In 1855, Kenner was founded by Minor Kenner on land that consisted of three plantation properties that had been purchased by the Kenner family. At the time, all land north of what is now Airline Highway was swampland.

Kenner's growth began in the late 1950s when developers began subdividing, draining and filling the swampland in the northern half of the city. During the 1960s, the construction of Interstate 10 and improvements to Veterans Memorial Highway aided the rapid development of Kenner as a suburb of New Orleans.

By 1979, Kenner's population was 60,524 making it the 6th largest city in state.